MIBG scintiscan

定义

An MIBG scintiscan is a type of imaging test. It uses a radioactive substance (called a tracer). A scanner finds or confirms the presence of 嗜铬细胞瘤 和 神经母细胞瘤. These are types of tumors that affect nerve tissue.

选择的名字

Adrenal medullary imaging; Meta-iodobenzylguanidine scintiscan; 嗜铬细胞瘤 - MIBG; 神经母细胞瘤 - MIBG; Carcinoid MIBG

How the Test is Performed

放射性同位素(MIBG, iodine-131-meta-iodobenzylguanidine, or iodine-123-meta-iodobenzylguanidine) is injected into a vein. This compound attaches to specific tumor cells.

You will have the scan later that day or the next day. For this part of the test, you lie on a table under the arm of the scanner. Your abdomen is scanned. You may need to return for repeated scans for 1 to 3 days. Each scan takes 1 to 2 hours.

Before or during the test, you may be given an iodine mixture. This prevents your thyroid gl和 from absorbing too much of the radioisotope.

How to Prepare for the Test

You will need to sign an informed consent form. You will be asked to wear a hospital gown or loose-fitting clothes. You will need to remove jewelry or metal objects before each scan. Many drugs interfere with the test. Ask your health care provider which of your regular medicines you may need to stop taking before the test.

How the Test will Feel

You will feel a sharp needle prick when the material is injected. The table may be cold or hard. You must lie still during the scan.

Why the Test is Performed

This test is done to help diagnose 嗜铬细胞瘤. 它完成时，一个 腹部CT扫描 或者一个 腹部核磁共振扫描 does not give a definite answer. It is also used to help diagnose 神经母细胞瘤 和 can be used for carcinoid tumors.

正常的结果

There are no signs of a tumor.

What Abnormal Results Mean

Abnormal results may indicate:

• 嗜铬细胞瘤
• Multiple endocrine neoplasia (MEN) II
• 类癌肿瘤
• 神经母细胞瘤

风险

There is some exposure to radiation from the radioisotope. The radiation from this radioisotope is higher than from many others. You may need to take extra precautions for a few days after the test. Your provider will tell you what actions to take.

Before or during the test, you may be given an iodine solution. This will keep your thyroid gl和 from absorbing too much iodine. Usually people take potassium iodide for 1 day pri或者一个d 6 days after. This blocks the thyroid from taking up the MIBG.

This test should not be done on pregnant women. The radiation can pose danger to the unborn baby.

参考文献

Bleeker G, Tytgat GAM, Adam JA, et al. 123I-MIBG scintigraphy 和 18F-FDG-PET imaging for diagnosing 神经母细胞瘤. Cochrane Database Syst Rev. 2015; (9): CDC009263. PMID: 26417712 pubmed.ncbi.nlm.国家卫生研究院.gov / 26417712 /.

科恩DL，菲什拜因L. Secondary hypertension: 嗜铬细胞瘤 和 paraganglioma. In: Bakris GL, Sorrentino MJ, eds. Hypertension: A Companion to Braunwald's Heart Disease. 3日艾德. Philadelphia, PA: Elsevier; 2018:chap 15.

奥伯格K. Neuroendocrine tumors 和 related disorders. In Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, et al, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 45.

Yeh MW, Livhits MJ, Duh Q-Y. 肾上腺. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21艾德. Philadelphia, PA: Elsevier; 2022:chap 40.